Analysis of publically available skin sensitization data from REACH registrations 2008-2014
نویسندگان
چکیده
منابع مشابه
Analysis of Publically Available Skin Sensitization Data from REACH Registrations 2008–2014
The public data on skin sensitization from REACH registrations already included 19,111 studies on skin sensitization in December 2014, making it the largest repository of such data so far (1,470 substances with mouse LLNA, 2,787 with GPMT, 762 with both in vivo and in vitro and 139 with only in vitro data). 21% were classified as sensitizers. The extracted skin sensitization data was analyzed t...
متن کاملAnalysis of Publically Available Skin Sensitization Data from REACH
135 Received October 5, 2015; Accepted January 26, 2016; Epub February 11, 2016; http://dx.doi.org/10.14573/altex.1510055 format and any workflows involving the public summary data in REACH depend on a slow and error-prone process of manual extraction. Here, we seek to demonstrate the extent and diversity of the public REACH dataset – a dataset that far surpasses most existing datasets used for...
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The European Chemicals Agency, ECHA, made available a total of 13,832 oral toxicity studies for 8,568 substances up to December 2014. 75% of studies were from the retired OECD Test Guideline 401 (11% TG 420, 11% TG 423 and 1.5% TG 425). Concordance across guidelines, evaluated by comparing LD50 values ≥ 2000 or < 2000 mg/kg body weight from chemicals tested multiple times between different guid...
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The European Chemicals Agency (ECHA) warehouses the largest public dataset of in vivo and in vitro toxicity tests. In December 2014 this data was converted into a structured, machine readable and searchable database using linguistic search engines. It contains data for 9,801 unique substances, 3,609 unique study descriptions and 816,048 study documents.This allows exploring toxicological data o...
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Public data from ECHA online dossiers on 9,801 substances encompassing 326,749 experimental key studies and additional information on classification and labeling were made computable. Eye irritation hazard, for which the rabbit Draize eye test still represents the reference method, was analyzed. Dossiers contained 9,782 Draize eye studies on 3,420 unique substances, indicating frequent retestin...
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ژورنال
عنوان ژورنال: ALTEX
سال: 2016
ISSN: 1868-596X
DOI: 10.14573/altex.1510055